WHAT IS OUR SPECIALTY TREATMENT FOR DEPRESSION?
Our FDA-approved nasal spray is prescribed for treatment-resistant depression. Unlike oral antidepressants, which can take several weeks to months to work, the effects of this advanced therapy are typically felt within days, unlocking a pathway to healing for patients who have not responded to oral antidepressants and/or other augmentative therapies alone.
​This treatment is the first new option approved for depression by the Federal Drug Administration (FDA) in decades. It is specially designed for those suffering from Treatment Resistant Depression (TRD). If you are currently diagnosed with depression and have not responded well to at least two different oral antidepressants, you may qualify for this therapy.
​This medication is derived from a well-known anesthetic that has been used in hospitals since the 1970s. Its help in alleviating symptoms of depression is a more recent discovery. This nasal spray for depression is unique in that it is self-administered in an office setting under the supervision of a healthcare provider.
HOW DOES IT WORK?
Standard antidepressants increase the naturally occurring chemicals in your body such as serotonin, dopamine, and norepinephrine to enhance communication between brain cells. This innovative treatment follows the same path but increases your glutamate levels, which are the most abundant chemical messenger in your brain. This gives you a greater impact on more brain cells at once.
WHAT ARE THE SIDE EFFECTS?
Like anything else, there are potential side effects associated with treatment. Side effects will usually lessen with each session as your body adjusts to the medication. Some things to expect include nausea, drowsiness, headaches, dizziness, feelings of intoxication, and increased blood pressure. You can read more about potential contraindications or side effects in the Medication Guide linked at the bottom of the page. Some patients also can experience more extreme side effects, including hallucinations and feeling disconnected from themselves and their surroundings. Therefore, it is vital for treatment to be done in a safe and controlled environment where the patient can be monitored.
What is the treatment schedule?
For the first four weeks, you can expect to come into the office twice weekly for treatment. During weeks 5 to 8 of treatment, you can expect to come in once weekly. For week 9 and after, depending on the efficacy/rate of remission, the patient and provider will determine if they should remain weekly or titrate down to biweekly.
Patients in this treatment program should expect to be at the office for a minimum of two hours on a treatment day. You will have your blood pressure taken prior to administration, halfway through treatment, and then one last time at the end. Staff will monitor you throughout your treatment period. Patients will need to have a ride home from treatment and should not drive or operate heavy machinery until having a restful night’s sleep.
WHAT IS THE DOSING?
HOW IS IT ADMINISTERED? The treatment is given as a spray through the nose. Each device contains a specific dose for each nostril. The dosing is determined by your provider during your first treatment; after that, you and your provider may decide whether to continue with the initial dose or to increase it.
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